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Home - Products - Angiogenesis - Adrenergic Receptor - BI 167107

BI 167107

CAS No. 1202235-68-4

BI 167107 ( BI167107 )

Catalog No. M10729 CAS No. 1202235-68-4

BI 167107 is a highly potent agonist of the β2 adrenergic receptor (β2AR) and β1AR (IC50=3.2 nM) and shows some activity as α1A antagonist (IC50 = 32 nM).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    BI 167107
  • Note
    Research use only, not for human use.
  • Brief Description
    BI 167107 is a highly potent agonist of the β2 adrenergic receptor (β2AR) and β1AR (IC50=3.2 nM) and shows some activity as α1A antagonist (IC50 = 32 nM).
  • Description
    BI 167107 is a highly potent agonist of the β2 adrenergic receptor (β2AR) and β1AR (IC50=3.2 nM) and shows some activity as α1A antagonist (IC50 = 32 nM); due to its high potency and slow dissociation from the target BI-167107 was subsequently used to support crystallization of active state β2AR and β2AR-G-protein complexes.
  • Synonyms
    BI167107
  • Pathway
    Angiogenesis
  • Target
    Adrenergic Receptor
  • Recptor
    Adrenergic Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1202235-68-4
  • Formula Weight
    370.45
  • Molecular Formula
    C21H26N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(N1)COC2=C1C(O)=CC=C2C(CNC(C)(C)CC3=C(C)C=CC=C3)O
  • Chemical Name
    5-hydroxy-8-(1-hydroxy-2-((2-methyl-1-(o-tolyl)propan-2-yl)amino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Weiss DR, et al. ACS Chem Biol. 2013 May 17;8(5):1018-26.
2. Ring AM, et al. Nature. 2013 Oct 24;502(7472):575-579.
3. Manglik A, et al. Cell. 2015 May 21;161(5):1101-1111.
4. Kahsai AW, et al. Nat Chem Biol. 2016 Sep;12(9):709-16.
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